Benoukraf Lab
Integrative Omics Approaches to Studying Epigenomic Drift in Disease
Our hybrid laboratory (combining wet and dry methods) focuses on developing computational tools and producing sequencing datasets for analyzing multi-omics interactions in the context of epigenomics drift.
Our research is divided into three main axes:
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Investigating the chromatin dynamics regulated by transcription factors in the context of epigenomic drift.
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Investigating the contribution of the microbiome in the epigenomic drift.
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Investigating the contribution of the epigenomic drift in genome instability.
Overall, using integrative approaches, our laboratory’s goal is to deepen our understanding of epigenomic drift and its underlying mechanisms. By analyzing these different omics layers, we aim to better describe and understand the role of epigenomic drift in pathophysiology.
NanoVar
Structural variant caller for low-depth Nanopore Sequencing in Patients’ samples
MethMotif
A transcription factor binding motifs database coupled with DNA methylation profiles
TFRegulomeR
Characterization of transcription factors’ context-specific features and functions
Impact de la méthylation de l’ADN sur la régulation transcriptionnelle
Biologie computationnelle des systèmes
9 Novembre 2022 à 14h
Université Saint Joseph de Beyrouth
DNA sequencing technologies
Module MED 6591
November 29th 2022, 2.00pm – 5.00pm
Memorial University of Newfoundland
Future of Genetics
Class of 2025 / Phase 3 Schedule
Future of Genetics
January 20th, 2023 11.30am (1M101)
Memorial University of Newfoundland
DNA sequencing technologies
Module CDM5104
January 27th 2023 4.00pm – 6.00pm.
National University of Singapore
Medical Genetics/Cancer and Development Seminar Series
Modules MED6400 / MED6412
January 23rd – April 24th, 2023 – 12.00pm (schedule available on D2L)
Memorial University of Newfoundland
Touati Benoukraf, PhD
Principal Investigator
Canada Research Chair in Bioinformatics for Personalised Medicine & Assistant Professor | Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland
Visiting Assistant Professor & co-Head: Genomics and Data Analytics Core (GeDaC) at the Cancer Science Institute of Singapore, National University of Singapore
Dr. Akinola A. Alafiatayo
MoH-TFRI / MITACS Post Doctoral Fellow
Omics in Colorectal Cancer
Dr. Hayley Alloway-Pike
Post Doctoral Fellow
Chromatin Structure
Dr. Modeline Longjohn
MoH-TFRI / MITACS Post Doctoral Fellow
Cancer Bioinformatics
Zia Hasan
PhD Student (Neuro – Qi lab)
Alzheimer’s single cell omics interplays
Matthew Dyer
PhD Student (Genetics)
DNA methylation dynamics
MethMotif maintenance
Asmaa Mahmoud
PhD student (Genetics)
Characterization of structural variants and repetitive elements
Tian Qin
PhD Student (Neuro – Qi lab)
Dynamics of single-cell brain epigenomics during fear communication
Sofiia Shapoval
Master’s Students (Genetics)
Transcription factors and DNA methylation interplays
Chen Xiang
Master’s Student (Comp. Sci.)
Z-stack images processing
Zahra Vafadoost
Master’s Student (Genetics)
Microbiome analysis
Pipeline development
Gastongay Siu
Master’s Student (Genetics)
Computational epigenomics methods
Jason Huan
Professional Associate (Invited)
Full-stack software developer
Very delighted to have shared science with high school students during Discovery Day @ Memorial University. We hope we were able to instill a passion for genomics in these future bright scientists.
Very delighted to meet Fred Fox, Terry Fox‘s brother, who was a Canadian athlete, humanitarian, and cancer research activist. The Terry Fox Research Institute, which was named in honor of Terry Fox, is a key player in cancer research in Canada, and one of our sponsors.
Seminar on structural variations in Leukemia. Invited speakers: Touati Benoukraf.
TAGC, Aix-Marseille University, France | December 16, 2022
Conference on Microbiome. Poster presentation: Akinola A. Alafiatayo.
Cold Spring Harbor, NY, USA | October 25 – 29, 2022
Invited speaker (TB) at the Toronto Bioinformatics Users Group seminar.
Toronto, ON, Canada | Feb. 24th, 2021.
Epigenetics in Cancer Symposium 2021. Our team is invited to talk (TB) and Matthew is presenting a poster on MethMotif.org.
NUS – Singapore | Feb. 15-17, 2021